Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1333)
DME Name Methylenetetrahydrofolate dehydrogenase (folD), Blautia producta
Synonyms Methenyltetrahydrofolate cyclohydrolase; Bifunctional protein FolD; C3R19_22270; PMF13cell1_04275; folD
Gene Name folD
UniProt ID
A0A2S4GHV2_9FIRM
EC Number    EC: 1.5.1.5     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.5
Lineage    Species: Blautia producta     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Blautia
Species: Blautia producta
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MAKRLLGKEVTAALNERIKADVAALEEKGVKPTLCIIRVGENESDISYERGATKRCETLG
VACEKILLPADVSQEELLATIDKVNKDDKIHGVLLFRPLPKHLNQSVIENALDPAKDVDC
MTDGSMSGVFTGKNVGFPPCTPQACMEILDFYGIDCTGKKAVVVGRSLVVGKPAAMMLIK
KNATVTICHTRTVDMPSVVREADIVIVAAGRAGVIDDTYLSAGQTVIDVGINVNAEGKLC
GDVDFEKAEPVVDAITPVPGGVGSVTTSVLVGHVVEAAKRKFA
Pathway Carbon metabolism (bpro01200 )
Metabolic pathways (bpro01100 )
Microbial metabolism in diverse environments (bpro01120 )
One carbon pool by folate (bpro00670 )
Function This enzyme catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
ISO-901
 Drug Info Phase 1 Rheumatoid arthritis ICD11: FA20 [1], [2]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
ISO-901
 Drug Info Phase 1 Rheumatoid arthritis Km = 27000 microM [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003931 ISO-901 10-formyl-tetrahydrofolate Oxidation - Oxidationn ISO-901 [3]
References
1 Purification and characterization of NADP(+)-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Peptostreptococcus productus marburg. J Bacteriol. 1991 Feb;173(4):1414-9.
2 Characterization of NAD-dependent 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus. Biochim Biophys Acta. 1989 Aug 8;1004(2):230-8.
3 Quantitative flux analysis reveals folate-dependent NADPH production

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