Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1355)
DME Name Unclear metabolic mechanism (DME-unclear), Akkermansia muciniphila
Gene Name DME-unclear
Lineage    Species: Akkermansia muciniphila     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Verrucomicrobia
Class: Verrucomicrobiae
Order: Verrucomicrobiales
Family: Akkermansiaceae
Genus: Akkermansia
Species: Akkermansia muciniphila
Subspecies: Akkermansia muciniphila ATCC BAA-835
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        13 Drugs
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Tacrolimus
 Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Finasteride
 Drug Info Approved Prostatic hyperplasia ICD11: GA90 [1]
Riluzole
 Drug Info Approved Amyotrophic lateral sclerosis ICD11: 8B60 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Pimozide
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Itraconazole
 Drug Info Approved Blastomycosis ICD11: 1F22 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          5 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Naftopidil
 Drug Info Phase 4 Prostatic hyperplasia ICD11: GA90 [1]
Trimebutine
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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