Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1466)
DME Name Cytochrome P450 154C2 (cyp154), Streptomyces avermitilis
Synonyms Cytochrome P450 family 154 subfamily C member 2; Cytochrome cyp154C2; P450 154C2; cyp154C2
Gene Name cyp154C4-2
UniProt ID
A0A345AH95_STRSQ
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Streptomyces avermitilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces avermitilis
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTRIALDPFVRDLDGESAALRAAGPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDIN
VWNAWQRGEIPADWPLIGLVNPGRSMLTVDGPDHRRLRTLVAQALTVKRVEKLRAGIEAL
TNASLERLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLKELFEKFFSTQTPP
EEVPQMMADLGTLFTKIVEEKKANPGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAGH
ETTISLIVNVVEALAIHPEQRKKVLSGEIPWEGVIEETLRWNTPTSHVLIRFATEDIEVG
DKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATRTPNRHIAFGHGPHVCPGAALSRLEA
GIALPALYERFPELDLAVPAAELRNKPIVTQNDLHDLPVKLGCPFGHDA
Function This enzyme is P-450 heme-thiolate protein, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Testosterone cypionate
 Drug Info Approved Testosterone deficiency ICD11: 5A81 [1], [2]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
Testosterone cypionate
 Drug Info Approved Testosterone deficiency Km = 160 microM [1], [2]
References
1 Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2020 Feb 5;522(2):355-361.
2 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.

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