Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1466)
DME Name Cytochrome P450 154C2 (cyp154), Streptomyces avermitilis DME Info
UniProt ID
A0A345AH95_STRSQ
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Streptomyces avermitilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces avermitilis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Testosterone cypionate Click to Show/Hide the Full List of HOSPPI:      19 HOSPPI
                            Aromatase (CYP19A1) Click to Show/Hide the Cometabolization Info
DME ID DME0002 DME Info
Uniprot ID
CP19A_HUMAN
Interaction Name CYP19A1-cyp154 interaction [1], [2], [3]
Description The interaction, between human Aromatase and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp154 interaction [1], [2], [4]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-cyp154 interaction [1], [2], [5]
Description The interaction, between human Cytochrome P450 1A1 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1B1 (CYP1B1) Click to Show/Hide the Cometabolization Info
DME ID DME0023 DME Info
Uniprot ID
CP1B1_HUMAN
Interaction Name CYP1B1-cyp154 interaction [1], [2], [6]
Description The interaction, between human Cytochrome P450 1B1 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2A13 (CYP2A13) Click to Show/Hide the Cometabolization Info
DME ID DME0030 DME Info
Uniprot ID
CP2AD_HUMAN
Interaction Name CYP2A13-cyp154 interaction [1], [2], [7]
Description The interaction, between human Cytochrome P450 2A13 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2B6 (CYP2B6) Click to Show/Hide the Cometabolization Info
DME ID DME0020 DME Info
Uniprot ID
CP2B6_HUMAN
Interaction Name CYP2B6-cyp154 interaction [1], [2], [8]
Description The interaction, between human Cytochrome P450 2B6 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-cyp154 interaction [1], [2], [9]
Description The interaction, between human Cytochrome P450 2C8 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp154 interaction [1], [2], [10]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp154 interaction [1], [2], [11]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A43 (CYP3A43) Click to Show/Hide the Cometabolization Info
DME ID DME0022 DME Info
Uniprot ID
CP343_HUMAN
Interaction Name CYP3A43-cyp154 interaction [1], [2], [12]
Description The interaction, between human Cytochrome P450 3A43 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp154 interaction [1], [2], [13]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-cyp154 interaction [1], [2], [14]
Description The interaction, between human Cytochrome P450 3A7 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 4B1 (CYP4B1) Click to Show/Hide the Cometabolization Info
DME ID DME0010 DME Info
Uniprot ID
CP4B1_HUMAN
Interaction Name CYP4B1-cyp154 interaction [1], [2], [15]
Description The interaction, between human Cytochrome P450 4B1 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Dehydrogenase/reductase retSDR3 (HSD17B14) Click to Show/Hide the Cometabolization Info
DME ID DME0609 DME Info
Uniprot ID
DHB14_HUMAN
Interaction Name HSD17B14-cyp154 interaction [1], [2], [16]
Description The interaction, between human Dehydrogenase/reductase retSDR3 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Farnesol dehydrogenase (AKR1B15) Click to Show/Hide the Cometabolization Info
DME ID DME0399 DME Info
Uniprot ID
AK1BF_HUMAN
Interaction Name AKR1B15-cyp154 interaction [1], [2], [17]
Description The interaction, between human Farnesol dehydrogenase and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp154 interaction [1], [2], [18]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Steroid 5-alpha-reductase 1 (SRD5A1) Click to Show/Hide the Cometabolization Info
DME ID DME0204 DME Info
Uniprot ID
S5A1_HUMAN
Interaction Name SRD5A1-cyp154 interaction [1], [2], [19]
Description The interaction, between human Steroid 5-alpha-reductase 1 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Steroid 5-alpha-reductase 2 (SRD5A2) Click to Show/Hide the Cometabolization Info
DME ID DME0218 DME Info
Uniprot ID
S5A2_HUMAN
Interaction Name SRD5A2-cyp154 interaction [1], [2], [19]
Description The interaction, between human Steroid 5-alpha-reductase 2 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Steroid 5-alpha-reductase 3 (SRD5A3) Click to Show/Hide the Cometabolization Info
DME ID DME0219 DME Info
Uniprot ID
PORED_HUMAN
Interaction Name SRD5A3-cyp154 interaction [1], [2], [19]
Description The interaction, between human Steroid 5-alpha-reductase 3 and Cytochrome P450 154C2 from Streptomyces avermitilis which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2020 Feb 5;522(2):355-361.
2 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
3 Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease? Brain Res Rev. 2008 Mar;57(2):431-43.
4 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
5 Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30.
6 Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis. 1999 Aug;20(8):1607-13.
7 Effects of 8-methoxypsoralen on cytochrome P450 2A13. Carcinogenesis. 2005 Mar;26(3):621-9.
8 Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425.
9 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
10 Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7.
11 Digging deeper into CYP3A testosterone metabolism: kinetic, regioselectivity, and stereoselectivity differences between CYP3A4/5 and CYP3A7. Drug Metab Dispos. 2017 Dec;45(12):1266-1275.
12 cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol. 2001 Feb;59(2):386-92.
13 In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44.
14 Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):15-28.
15 Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch Biochem Biophys. 1991 Oct;290(1):160-6.
16 Expression patterns of 17beta-hydroxysteroid dehydrogenase 14 in human tissues. Horm Metab Res. 2012 Dec;44(13):949-56.
17 Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45.
18 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
19 Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11).

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