Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1524)
DME Name Cytochrome P450 101D1 (cyp101), Novosphingobium aromaticivorans
Synonyms Cytochrome P450 family 101 subfamily D member 1; Cytochrome P450-cam D1, Cytochrome P450cam D1; P450 101D1; cyp101D1
Gene Name cyp101
UniProt ID
Q2GB12_NOVAD
EC Number    EC: 1.14.15.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.1
Lineage    Species: Novosphingobium aromaticivorans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Sphingomonadales
Family: Sphingomonadaceae
Genus: Novosphingobium
Species: Novosphingobium aromaticivorans
Subspecies: Novosphingobium aromaticivorans DSM 12444
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNAQTSTATQKHRVAPPPHVPGHLIREIDAYDLDGLEQGFHEAWKRVQQPDTPPLVWTPF
TGGHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKG
LNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTVFPVRVFLALAGLPVEDATKLG
LLANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAARRGGSGTDLITRILNVEIDGKP
MPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRREPLKLQRGVEELFRRF
AVVSDARYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSRRDVTHSTFAQ
GPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPIYHSGIVAAVENIPLEWEPQRVS
A
Structure
3LXH ; 3LXI ; 4C9K ; 4C9L ; 4C9M ; 4C9N ; 4C9O ; 4C9P
Function This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-1907611
 Drug Info Phase 3 Inflammatory bowel disease ICD11: DD72 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR000454 BRN-1907611 5-Exo-hydroxycamphor Oxidation - Hydroxylation BRN-1907611 [1], [2]
References
1 A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.
2 DrugBank(Pharmacology-Metabolism)BRN-1907611

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