Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1562)
DME Name Beta-lactamase (blaB), Corynebacterium acnes
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; HMPREF0675_4578
Gene Name blaB
UniProt ID
D4HFC4_CUTAS
Gene ID
2932324
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Corynebacterium acnes     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Propionibacteriales
Family: Propionibacteriaceae
Genus: Cutibacterium
Species: Corynebacterium acnes
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MTDSVLDVTADALEQAGAHPHRLVVRQHGQVVGRRRWAPWSPDVPSLVYSCSKTFTSAAV
GIAVNRGAFGYDDTLADLWPQACTANTGPVAKSMTVRNALSMSTGHSPEQLLEPTLMSRR
LPDLNTARILLATEPEGRPGIDFAYNNLATWMLSRLVAQHTGEDVDTIITKEVLDPIGAG
PHTWVRDADGIPMGFSGLHIDAEDLSLFGQLLLDDGVHEGARLLPEEWIRQHRVRQVNCD
SETDPEWGMGYGWQTWMSSHGYRLDGAFGQYVLIVPEVDAVITMTNEASEGPGDKQAILQ
AVWDHLLPALADGFQPQPEEIVRTVPTVTGEFDSARSVQGIAPDGSYIVVSPHKESRTWA
MSWRCPGTFSHPTDETLDIAVGYEEWQTSHCRVGDDAIDIATSGGWQGETFVARLCVIST
PHTLTLRMTPEATTTEWDNEPLNPGGLLGLVHPELRR
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
References
1 Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.

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