Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1562)
DME Name Beta-lactamase (blaB), Corynebacterium acnes DME Info
UniProt ID
D4HFC4_CUTAS
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Corynebacterium acnes     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Propionibacteriales
Family: Propionibacteriaceae
Genus: Cutibacterium
Species: Corynebacterium acnes
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Hagfish HFIAP-1/2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03556   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-1/2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes (MIC = 2 ug/ml) [1]
                              Hagfish HFIAP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03557   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-3 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes (MIC = 2 ug/ml) [1]
                              Hematopoietic antimicrobial MgCath37 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03540   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hematopoietic antimicrobial MgCath37 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [1]
                              Mutacin II mutacin H-29B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04156   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mutacin II mutacin H-29B inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [2]
                              Pleurocidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04640   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [3]
                              Temporin-Dra T5k Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01826   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-Dra T5k inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes (MIC = 6 microM) [4]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        6 Xenobiotics
                              Acetylcysteine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00110   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetylcysteine inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [5]
                              Benzoyl peroxide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00389   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Benzoyl peroxide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [6]
                              Clindamycin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00240   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Clindamycin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [6]
                              Erythromycin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00111   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Erythromycin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [6]
                              Minocycline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04116   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Minocycline inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [6]
                              Oxytetracycline Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00202   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Oxytetracycline inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [6]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Rhodomyrtone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04854   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Rhodomyrtone inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [7]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              (Z)-5-decylidenethiazolidine-2,4-dione Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01807   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation (Z)-5-decylidenethiazolidine-2,4-dione inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [6]
                              (Z)-5-octylidenethiazolidine-2,4-dione Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01808   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation (Z)-5-octylidenethiazolidine-2,4-dione inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [6]
                              Decanediol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03088   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Decanediol inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Corynebacterium acnes [8]
References
1 Hagfish intestinal antimicrobial peptides are ancient cathelicidins. Peptides. 2003 Nov;24(11):1655-67.
2 Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans. J Bacteriol. 1994 Jul;176(14):4316-20.
3 Antimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity. Biochim Biophys Acta. 2012 Dec;1820(12):1831-8.
4 Peptides with antimicrobial and anti-inflammatory activities that have therapeutic potential for treatment of acne vulgaris. Peptides. 2012 Apr;34(2):275-82.
5 N-acetylcysteine inhibits growth, adhesion and biofilm formation of Gram-positive skin pathogens. Microb Pathog. 2017 Apr;105:145-152.
6 Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms. J Appl Microbiol. 2014 Mar;116(3):492-501.
7 Rhodomyrtone inhibits lipase production, biofilm formation, and disorganizes established biofilm in Propionibacterium acnes. Anaerobe. 2017 Feb;43:61-68.
8 Inhibition of Propionibacterium acnes associated biofilm formation by Decanediol. J Dermatol Sci. 2016 Aug;83(2):159-61.

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