Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1642)
DME Name Endoglucanase Y (EGY), Lactobacillus johnsonii
Synonyms Endo-1,4-beta-glucanase Y; SGNH_hydro domain-containing protein Y; Cellulase Y; EGY; CBG24_05650
Gene Name EGY
UniProt ID
A0A256VAC0_LACRE
EC Number    EC: 3.2.1.136     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.136
Lineage    Species: Lactobacillus johnsonii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus johnsonii
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKYQPTDLIKFASRTGRWTIKKLDNSPTLYTTNLGSYLRFKVSDAKKCQITVLPNQNSL
SPSQVFAFRIDGGKWQRAQASLEKIDIPLDSTLHTIEIMAAGNTDIDEVWQGNEGFAIKN
IYLDRGEITAAPQRPLINFIGDSITAGCWVVGNHPAADYRPETNYAGICADLLNVDSVRI
AYSAGGVLRPATGGVPTADVFLGKIDNQTLWTPNHPDLNVINLGVNDRRFPLTQFIAAFD
LFIQQVKLTFPHTPLAIIIPFSQTFASAIRTIATKHDCSIIETKTWHHSFTDGLHPDQAG
AINEGKMLAQALQPLLPQFSVQ
Function This enzyme hydrolyzes 1,4-linkages in beta-D-glucans also containing 1,3-linkages.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          4 Drugs
Amikacin
 Drug Info Approved Pseudomonas infection ICD11: 1G40 [1]
Gentamicin
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [1]
Kanamycin
 Drug Info Approved Pulmonary tuberculosis ICD11: 1B10 [1]
Streptomycin
 Drug Info Approved Infectious endocarditis ICD11: BB40 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Colistin
 Drug Info Phase 4 Pneumocystis pneumonia ICD11: CA40 [1]
References
1 Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.

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