Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1643)
DME Name Beta-lactamase (blaB), Chromobacterium violaceum
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; NCTC9695_01822
Gene Name ampC
UniProt ID
A0A3S4HKA9_CHRVL
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Chromobacterium violaceum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Chromobacteriaceae
Genus: Chromobacterium
Species: Chromobacterium violaceum
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MMQSLKFRTLAGMLGCLTFLPLAAQAANDAGKSDLDAAVEATIPPLMKAKDIPGMAVAVL
ADGKAHYFNYGVASRETGQPVTQDTLFELGSISKTFTGILGGYALAQGKLSLADKASRYQ
PELKGSVFDRVSLLQLATYSAGGLPLQFPDAVAGQASMLAYYRGWKPDYAPGERRLYSNP
SIGLFGHLAARSLGQPFDQAMERGLLPKLGLSHTFIHVPEAEQSRYAWGYAKAGKPIRVG
AGVLDAEAYGIKSSAADLLKYLAINMSPPADPALQRALDASHAAYYRVGDMRQGLGWEGY
RYPISLERLLAGNSNEIAFQPQKVEWLNPPRLAEGDVLLNKTGSTSGFGAYVLFVPARKV
GIVMLANRNYPNAERVRAAYRILLAVDPSLARRRGD
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          3 Drugs
Cefoxitin
 Drug Info Approved Peritonitis ICD11: DC50 [1]
Carbenicillin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
Ticarcillin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
References
1 Beta-lactamase activity in Chromobacterium violaceum. J Infect Dis. 1976 Sep;134(3):290-3.

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