Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1678)
DME Name GH3 beta-glucosidase (BAD1610), Bifidobacterium adolescentis
Synonyms Periplasmic beta-glucosidase GH3; Glucan endo-1 3-beta-D-glucosidase GH3; Beta-D-glucosidase GH3; Beta-D-glucoside glucohydrolase GH3; Beta-glucosidase GH3; GH3; BAD_1610
Gene Name BAD1610
UniProt ID
A1A3V8_BIFAA
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Bifidobacterium adolescentis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium adolescentis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTMPRSMYNHADKQEDKEKSYIELDSTETEIIKYLNDNYKDVILLVKSSAAMELDWLKQY
PNIKAVVYSQNVTNALAKVFSGEVNPSGRTVDTFAADALASPAAQNFGSYQYYDENGKAT
KYNYVDYAEGIYVGYKYYETRYEDKVLGQGNAGDYDYAKEVVYPFGYGLSYTDFKWSDFS
VARHGNDFVATVTVTNTGDTAGKDVVELYAQSPYTDYDKRNAVEKASVNLVGYGKTSELK
PGTSETVRITFGKDQLKAYDYKGAKTYILDAGQYRFTAATDANQAVNNILADKGKTVADG
MTSEGDKTMVASWTPENTDADTTTFASDSTTGKAISNLFDAASDPEVAYLSRSDWTGTFP
KHYGESSGEINTWGNEINCKDSDGNNASCTWKKTASTKLIKHLEGNDSGTTVDKDSIMDT
PTFGKKNGLKVSDMRGLAYDDAQWDKILDELTEDDYNQLIYFSGYGVDYIKSVDKPFQTD
ADSATGWMYGGTGKTFPSIMMLTQTWNAQLAEDLGEMMGNEALLGGANGWYAPAMNIHRT
PFSGRNGEYYSEDGYMSGSMASLEVKGAATKGVYSYIKHFALNDQENHRGDRPGNFSVAT
WSNEQAIREIYLKPFDMCMHLGDMDMKTVVKKSDGTYENKVVKTPIAKGVMTSFNRIGAT
WTGGSHALIQQLLRDEWGFNGLIITDNANTGKFMSPYQMLEAGADIKLLNVSDDPTGEKL
DFNDAATYHYARQAMHHLLYTVANTNCMNGALPGAGFKFSNGMKTIQIVFNTVCSVILAM
LAFFSVWRWMPGTIKRVAARKEARVARKAARKAAKG
Pathway Biosynthesis of secondary metabolites (bad01110 )
Cyanoamino acid metabolism (bad00460 )
Metabolic pathways (bad01100 )
Starch and sucrose metabolism (bad00500 )
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
PNB-D-glucoside
 Drug Info Investigative Discovery agent ICD: N.A. [1]
PNB-D-xyloside
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Structural and biochemical characterization of a GH3 beta-glucosidase from the probiotic bacteria Bifidobacterium adolescentis. Biochimie. 2018 May;148:107-115.

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