Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1829)
DME Name Dihydroorotase (pyrC), Faecalicatena orotica
Synonyms Carbamoylaspartic dehydrase; Dihydroorotate dehydrolase; Dihydroorotase; BcDHOase; DHOase; DHO; A8806_10260; SAMN05216536_10260; pyrC
Gene Name pyrC
UniProt ID
A0A2Y9B958_9FIRM
EC Number    EC: 3.5.2.3     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.3
Lineage    Species: Faecalicatena orotica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Faecalicatena
Species: Faecalicatena orotica
Subspecies: Faecalicatena orotica ATCC 25750
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MILIKNGRVIDPKSGMDETIDILIDEGKIVGLGKYKRSNEYEHVIEAEGKIVAPGLIDIH
VHFRDPGLTYKEDIESGALAAASGGFTTVVCMANTKPTVDNKETLEYVLEKGRQTGIHVM
SVAAVTKGMQGQELTDFRELKEAGAAGLSDDGIPIKDSKLMYEAMAKARDAGMPVSLHEE
DPDYVIQAGINKGTVSDELGIGGAMALSEQLMVARDCLLALETGARVNIQHVSSRISVEY
IRLAQKLGADVWAEATPQHFSLTEETALEKKTLAKVNPPLRTQEDRYGILEGLKDGTIQI
IATDHAPHSTEEKEKPITQAPSGLIGLETSLALGITNLVRTGILTMEYMLKKMTLNPARL
YGLDVGYIAKGAPADIVIFDEFEKWKVEKFHSKSCNSPFIGEELYGKVKYTICAGRIVYE
DK
Function This enzyme catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Dexrazoxane hydrochloride
 Drug Info Approved Breast cancer ICD11: 2C60 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
NSC-14983
 Drug Info Phase 1 Dyslipidaemia ICD11: 5C81 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR002596 Dexrazoxane metabolite B ADR-925 Hydrolysis - Hydrolysis Dexrazoxane hydrochloride [3], [4]
MR002597 Dexrazoxane metabolite C ADR-925 Hydrolysis - Hydrolysis Dexrazoxane hydrochloride [3], [4]
References
1 Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood Drug Metab Dispos. 2005 Jun;33(6):719-25. doi: 10.1124/dmd.104.003186.
2 Enzyme elements involved in the interconversion of L-carbamylaspartate and L-dihydroorotate by dihydroorotase from Clostridium oroticum. Arch Biochem Biophys. 1985 Dec;243(2):447-53.
3 Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood. Drug Metab Dispos. 2005 Jun;33(6):719-25.
4 Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation. Circ Heart Fail. 2021 Nov;14(11):e008209. doi: 10.1161/CIRCHEARTFAILURE.120.008209.

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