Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002597)
Formula Reactant Dexrazoxane metabolite C Product ADR-925
Reactant Info Product Info
Metabolic Enzyme Dihydroorotase (pyrC) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002599 Dexrazoxane hydrochloride Dexrazoxane metabolite C Hydrolysis - Hydrolysis Dexrazoxane hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002596 Dexrazoxane metabolite B ADR-925 Hydrolysis - Hydrolysis Dexrazoxane hydrochloride [1], [2]
References
1 Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood. Drug Metab Dispos. 2005 Jun;33(6):719-25.
2 Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation. Circ Heart Fail. 2021 Nov;14(11):e008209. doi: 10.1161/CIRCHEARTFAILURE.120.008209.

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