Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1842)
DME Name Beta-glucosidase (bglA), Bacteroides thetaiotaomicron
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; Btheta7330_04370; ERS852511_03465; SAMN02910322_04182; bglX_4; bglX_8
Gene Name bglX_4
UniProt ID
A0A0P0FEZ9_BACT4
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Bacteroides thetaiotaomicron     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides thetaiotaomicron
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKVIKIFSACLFLLPFVSCTQVTNDKGDTAIEKKVEALLSKMTLEEKLGQMNQITSYGNI
EDMSGLIKQGGAGSILNETDPVRINALQRVAIEESRLSIPLLMARDVIHGFKTIFPIPLG
QAASFNPQVAEDGARVAAIEASSVGIRWTFAPMIDIARDPRWGRMAEGCGEDTYLTTVMG
VAMVKGFQGDSLNSPTSIASCPKHFVGYGAAEGGRDYNSTFIPERRLRNVYLPPFEAASK
AGAATFMTSFNDNDGVPSTGNSFILKDVLRSEWGFDGLVVTDWASSTEMIAHGFAADSKE
VAMKAVNAGVDMEMVGNTFVKELPGLIKEGKVKEAEIDNAVRNILRIKYRLGLFENPYVD
EKANVLYAPSHLEAAKQAATESAILLKNDHETLPLQSSVKTIAIVGPMANAPYDQLGTWV
FDGEKSHTMTPLTAIKELADDKVQIIYEPGLTYSRDKNIAGVAKAAAAAARADVILAFVG
EEAILSGEAHCLADLNLQGAQSELISALAKTGKPVVTIVMAGRPLTIGKETELSSALLYS
FHPGTMGGPALADLLFGKAVPSGKTPVTFPKMVGQVPVYYAHNNTGRPATRSEVLIDDIA
LEAGQTSLGCTSFYMDAGFDPLFPFGYGLSYTTFQYGNVKLSSDNLKKDDVLTVTFDLEN
TGKYEGTEVAQLYVQDMIGSVTRPVKELKRFTRVTLKPGEKKTVSFELPISELAFWNIDM
VKTVEPGDFALWVAPDSQSGEKNLFKVVD
Pathway Biosynthesis of secondary metabolites (btho01110 )
Cyanoamino acid metabolism (btho00460 )
Metabolic pathways (btho01100 )
Starch and sucrose metabolism (btho00500 )
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
DB-041901
 Drug Info Phase 2 Opioid-induced constipation ICD11: DB32 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Ginsenoside Rb1
 Drug Info Investigative Obesity ICD11: 5B81 [2]
References
1 Gut microbiota-mediated drug-antibiotic interactions. Drug Metab Dispos. 2015 Oct;43(10):1581-9.
2 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.

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