Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1918)
DME Name Alcohol dehydrogenase (ADH), Lactobacillus brevis
Synonyms Alcohol dehydrogenase AdhP; Zinc-dependent alcohol dehydrogenase; Zn-dependent alcohol dehydrogenase; AZI09_07320; AZI11_05495; CCS05_05540; CNR29_05565; LbDm2_0383; NCTC13386_01440; UCCLBBS449_1499; adhA_1
Gene Name adhA_1
UniProt ID
A0A0C1PYK8_LACBR
Gene ID
4414258
EC Number    EC: 1.1.1.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.1
Lineage    Species: Lactobacillus brevis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus brevis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKAAVIRDSVDGYVDIKDVTLRPITHGEALVKMEYCGLCHTDLHVAAGDFGKQPGRIIGH
EGVGKVIQVADDVDNLKIGDRVSVAWFFKGCGHCEYCLTGRETLCRNVQNSGFTVDGAMA
EECIVDANYAVKVPEGLDPIEATSLTCAGVTMYKALKVGETKPGQWVEVVGAGGLGNLAI
QYAHNVFGAHVVAVDGNPDKLAAAKANGAEVLINRHDGNVAEQIQEKVGGVDNAQVTAVN
KDAFTQSVNALKPDGKLVAVALPQGDMELNIAKTVLDGISVRGSLVGTRQDLAETFQFGA
EGKVHPIVKTRRLDEVNDIIDEMKNNQIVGRMVVDFTK
Function This enzyme acts on primary or secondary alcohols or hemi-acetals with very broad specificity and the enzyme oxidizes methanol much more poorly than ethanol.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Prochiral ketones
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Neutron and X-ray crystal structures of Lactobacillus brevis alcohol dehydrogenase reveal new insights into hydrogen-bonding pathways. Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):754-764.

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