Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2850)
Drug Name
Prochiral ketones
Synonyms
4-CHLOROBENZOPHENONE; 134-85-0; (4-Chlorophenyl)(phenyl)methanone; Methanone, (4-chlorophenyl)phenyl-; Benzophenone, 4-chloro-; p-CBP; (4-chlorophenyl)-phenylmethanone; 4-chloro benzophenone; UNII-WIH1IZ728U; MFCD00000622; 4-Chlorobenzophenone, 99%; WIH1IZ728U; UGVRJVHOJNYEHR-UHFFFAOYSA-N; para-Chlorobenzophenone; HSDB 2740; 4-chlorobenzophenon; NSC 2872; p-Chlorobenzophenone; EINECS 205-160-7; PubChem3298; 4-Benzoylphenyl chloride; AI3-00705; Cetirizine Impurity (4-Chlorobenzophenone); ACMC-209bx7; p-Chlorophenyl phenyl ketone; 4-chlorophenyl phenyl ketone; DSSTox_CID_30242; DSSTox_GSID_51687; SCHEMBL50462; KSC176E1J; phenyl-(4-chlorophenyl)-ketone; CHEMBL3560455; DTXSID2051687; CTK0H6214; KS-00000IIV; Benzophenone, 4-chloro- (8CI); NSC2872; BCP27841; NSC-2872; STR01449; ZINC2504270; Tox21_304009; (4-Chlorophenyl)(phenyl)methanone #; ANW-19721; STL453116; AKOS000119405; CS-W004344; MCULE-3593125639; NE10043; PS-7925; RTR-031190; TRA0100086; NCGC00357224-01; AC-23664; AK-58316; CAS-134-85-0; AB1008297; DB-042255; TR-031190; FT-0618187; ST24026277; ST50308103; AH-034/32828041; W-108278; Q27292660; Z425389590; 4-Chlorobenzophenone, United States Pharmacopeia (USP) Reference Standard
Indication Discovery agent Investigative [1]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Alcohol dehydrogenase (ADH) DME1918 Lactobacillus brevis
A0A0C1PYK8_LACBR
1.1.1.1
[2]
References
1 Asymmetric hydrogenation of prochiral amino ketones to amino alcohols for pharmaceutical use. Acc Chem Res. 2007 Dec;40(12):1367-76.
2 Neutron and X-ray crystal structures of Lactobacillus brevis alcohol dehydrogenase reveal new insights into hydrogen-bonding pathways. Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):754-764.

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