Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1936)
DME Name Beta-glucosidase (bglA), Roseburia intestinalis
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; DW927_12715
Gene Name bglA
UniProt ID
A0A3R6A2W5_9FIRM
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Roseburia intestinalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
Species: Roseburia intestinalis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MFRDDFVWGVASSSYQVEGTDANDGRGKTVWDAFTEAGRIFENQNAYTTCDHMHHYKEDY
ALMKNLGIKAYRFSLNWARILPEGTGRVNEKAIRMYRDMITCMKENGITPYITMFHWEFP
QALYEKGGWLNPEVADWFGEYAKVVAERFSDICEYFITINEPQCVVGLGHLSGVHAPGVK
MSIKDTFQIAHNLMKAHGQAVINLRKYAVRDIKVGYAPTGGVAYPYTDKPEDIEAAKKVY
FGFYNPMDNWTWNVAWFSDPVFLGHYPKEGLEKFAQYLPEITEEDMKLIHQPLDFMGQNI
YNGYYVRAGENGEPEFVDREPGFPKTGADWPVTPEAFYYGIKFLTERYPLPLYITENGMS
CHDNISADGRVHDPNRITFLDSYIGAMQRASDEGADVRGYFLWTFLDNFEWSDGYKQRFG
IIYVDFTTQQRIVKDSAFWYQKVIETNGGILSMNQANKDILFLDPVCTHNIWGGTKLREE
FGYPVEGDDIGECWGISAHPNGDGTVRSGAFSGMKLSAVWKEHPEVFGNYDCDRFPLLTK
IIDARDDLSIQVHPNDDYAKVHENGSFGKTECWYIMDAPEGATLVIGHNAKTKEELSDMI
HQGRWKEFIREIPVKKGDFIQIDPGTVHAIKGGLLILETQQNSDITYRVYDYDRLSNGKP
RELHVEKSIDVITVPAKSVDDSVKSALNLPENQLNELYSCKYYTIFKADVNGKMEFEQKY
PFLLVSVLEGDGIVGSSPVKKGDHFILPNGYGKVEMQGKMSLIVSTVK
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Ginsenoside Rb1
 Drug Info Investigative Obesity ICD11: 5B81 [1]
References
1 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.

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