| General Information of DME (ID: DME1971) |
| DME Name |
Oxygen-insensitive NADPH nitroreductase A (nfsA), Salmonella enterica
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| Synonyms |
Oxygen-insensitive NAD(P)H nitroreductase A; Modulator of drug activity A; STM0874; mdaA; nfsA; pnrA; snrA
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| Gene Name |
nfsA
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 1.5.1.38 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.38
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| Lineage |
Species: Salmonella enterica (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium TA100
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MSPTIELLCGHRSIRHFTDEPVTDAQREAIIAAARSTSSSSFLQCSSIIRITDRALREAL
VPLTGGQKHVAQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMGQNALTAAE
SLGLGGVYIGGIRNNIESVTELLKLPKHVLPLFGLCLGWPADNPDLKPRLPAELVVHENQ
YQPLDEKLLARYDEQLAEYYLTRGSNTRRDTWSDHIRRTLIKENRPFILEYLHKQGWATR
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| Pathway |
Microbial metabolism in diverse environments (stm01120 ) |
| Nitrotoluene degradation (stm00633 ) |
| Function |
This enzyme catalyzes the reduction of nitroaromatic compounds using NADPH, and has a broad electron acceptor specificity. Moreover, it reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product.
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