Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2071)
DME Name Beta-lactamase (blaB), Bacillus pumilus
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; ybxI; AIDNDMCJ_13045
Gene Name ybxI
UniProt ID
A0A498U5Y1_BACPU
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Bacillus pumilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus pumilus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKKHMKWLFSGLMLMALCIGQPSSSEGTSPAWSVDEFIKDREGTFVIQEVKEKSPWVYN
KKRANERFAPQSTFKVANALIGLQTGAVRDEYDIKYWDGVKREIDNWNKDHTLGSGMRDS
VVWYYQAMARDIGEERMNHWVKAIHYGNEDISGGIDQFWLSSSLRISPVEQVHFLKQLYE
ESLPFDLSVMRTVKRMMIQEEEKHATLYGKTGSGSGIGWYVGFIKHENKTYIFATNIEGT
GLEAKEITYRILKKYHLIEASV
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Ceftiofur
 Drug Info Investigative Superficial thrombophlebitis ICD11: BD70 [1], [2]
References
1 Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet Microbiol. 2009 Oct 20;139(1-2):89-96.
2 MALDI-TOF identification of the human Gut microbiome in people with and without diarrhea in Senegal. PLoS One. 2014 May 1;9(5):e87419.

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