Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2102)
DME Name Phosphotransferase enzyme strA (strA), Erwinia amylovora
Synonyms Streptomycin phosphotransferase strA; Bacterial phosphotransferase strA; strA
Gene Name strA
UniProt ID
Q79DN3_ERWAM
Gene ID
40045105
EC Number    EC: 2.7.3.9     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.3.9
Lineage    Species: Erwinia amylovora     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Erwiniaceae
Genus: Erwinia
Species: Erwinia amylovora
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKG
RGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLSVDQC
PFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVV
CHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAV
LFNVLGIEAPDRERLAFYLRLDPLTWG
Function This enzyme is enzyme I of the phosphotransferase system, and it acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Streptomycin
 Drug Info Approved Infectious endocarditis ICD11: BB40 [1]
References
1 Genetic analysis of streptomycin-resistant (Sm(R)) strains of Erwinia amylovora suggests that dissemination of two genotypes is responsible for the current distribution of Sm(R) E. amylovora in Michigan. Phytopathology. 2011 Feb;101(2):182-91.

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