Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN129)
DME Name ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1), Homo sapiens
Gene Name BST1
UniProt ID
BST1_HUMAN
EC Number    EC: 3.2.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
N-Glycosyl compound glycosidase
EC: 3.2.2.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSP
EQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFA
DNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYS
KDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGE
GSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQ
RAGLIIPLFLVLASRTQL
Structure
1ISF ; 1ISG ; 1ISH ; 1ISI ; 1ISJ ; 1ISM
Function Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) . Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
SRT-647
 Drug Info Phase 1 Mitochondrial myopathy ICD11: 8C73 [1], [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
D-ribosylnicotinate
 Drug Info Investigative Discovery agent ICD: N.A. [3]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012867 D-ribosylnicotinate D-ribosylnicotinate Metabolite A4 Hydrolysis - Hydrolyzation D-ribosylnicotinate [3]
MR003985 SRT-647 Nicotinamide (NAM) Hydrolysis - Hydrolysis SRT-647 [1], [2]
References
1 Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
2 BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
3 A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157

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