Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN252)
DME Name #NAME?, Homo sapiens
Gene Name GGT
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Captopril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Sotorasib
 Drug Info Phase 3 Lung cancer ICD11: 2C25 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BP-12941
 Drug Info Phase 2 Prostate cancer ICD11: 2C82 [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Stachyose
 Drug Info Investigative Discovery agent ICD: N.A. [3]
Leukotriene C4
 Drug Info Investigative Discovery agent ICD: N.A. [4]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR007329 Glutathione conjugation Unclear Unclear - Unclear BP-12941 [2]
MR005374 LTD4 (Leukotriene D4) LTE4 (Leukotriene E4) Unclear - Unclear Leukotriene C4 [4]
References
1 Absorption, metabolism and excretion of [(14)C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate
2 Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. AAPS J. 2014 Jul;16(4):705-13.
3 Optimizing raffinose family oligosaccharides content in plants: A tightrope walk
4 Leukotriene C4 metabolism by hepatoma cells and liver

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