Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN746)
DME Name Deacetoxycephalosporin C synthetase (cefE), Streptomyces clavuligerus
Gene Name cefE
UniProt ID
B5GLB0_STRCL
EC Number    EC: 1.14.20.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
2-oxoglutarate donor oxidoreductase
EC: 1.14.20.1
Lineage    Species: Streptomyces clavuligerus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Streptomyces clavuligerus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MDTTVPTFSLAELQQGLHQDEFRRCLRDKGLFYLTDCGLTDTELKSAKDIVIDFFEHGSE
AEKRAVTSPVPTMRRGFTGLESESTAQITNTGSYSDYSMCYSMGTADNLFPSGDFERIWT
QYFDRQYTASRAVAREVLRATGTEPDGGVEAFLDCEPLLRFRYFPQVPEHRSAEEQPLRM
APHYDLSMVTLIQQTPCANGFVSLQAEVGGAFTDLPYRPDAVLVFCGAIATLVTGGQVKA
PRHHVAAPRRDQIAGSSRTSSVFFLRPNADFTFSVPLARECGFDVSLDGETATFQDWIGG
NYVNIRRTSKA
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Penicillin G Sodium
 Drug Info Approved Bacterial infection ICD11: 1A00-1C4Z [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008107 Penicillin G Sodium Phenylacetyl-7-aminodeacetoxycephalosporanic acid (G-7-ADCA) Unclear - Unclear Penicillin G Sodium [1]
References
1 Whole-Cell Biotransformation of Penicillin G by a Three-Enzyme Co-expression System with Engineered Deacetoxycephalosporin?C Synthase

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