Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN805)
DME Name Endonuclease (ENDO), Homo sapiens
Gene Name ENDO
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR010275 Fomivirsen sodium Fomivirsen sodium Metabolite M1 Unclear - Unclear Fomivirsen sodium [1]
MR011066 Fomivirsen sodium Oligonucleotides Unclear - Unclear Fomivirsen sodium [1]
MR011067 Fomivirsen sodium Mononucleotide Unclear - Unclear Fomivirsen sodium [1]
MR010282 Inotersen Inotersen Metabolite M1 Unclear - Unclear Inotersen [1]
MR010273 Mipomersen Mipomersen Metabolite M1 Unclear - Unclear Mipomersen [2]
References
1 Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs
2 Clinical pharmacological properties of mipomersen (Kynamro), a second generation antisense inhibitor of apolipoprotein B

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