Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN814)
DME Name Beta-Hydroxyacyl-CoA Dehydrogenase (HSDB), Homo sapiens
Gene Name HSDB
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR013769 Beta-Hydroxyphenylbutyryl-CoA Beta-Ketophenylbutyryl-CoA Unclear - Unclear phenylbutyrate [1]
MR011794 3-keto-5alpha-Gal 3beta-OH-5alpha-Gal Unclear - Unclear TOK-001 [2]
MR011792 3-keto-5beta-Gal 3beta-OH-5beta-Gal Unclear - Unclear TOK-001 [2]
MR011789 TOK-001 D4G Unclear - Unclear TOK-001 [2]
References
1 Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
2 Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities

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