Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN845)
DME Name	Beta-lactamase (bla OXA-48), Klebsiella pneumoniae
Gene Name	bla OXA-48
UniProt ID	Q6XEC0_KLEPN
EC Number	EC: 3.5.2.6 (Click to Show/Hide the Complete EC Tree) Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Klebsiella pneumoniae (Click to Show/Hide the Complete Species Lineage) Kingdom: . Phylum: . Class: . Order: . Family: . Genus: . Species: Klebsiella pneumoniae
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence	MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLK RANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVV PVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNK LHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMD MPTSDGLGLRQAITKEVLKQEKIIP
Structure	3HBR ; 4S2J ; 4S2K ; 4S2N ; 4S2P ; 4WMC ; 5DTK ; 5DTS ; 5DTT ; 5DVA ; 5FAQ ; 5FAS ; 5FAT ; 5HAP ; 5HAQ ; 5OFT ; 5QA4 ; 5QA5 ; 5QA6 ; 5QA7 ; 5QA8 ; 5QA9 ; 5QAA ; 5QAB ; 5QAC ; 5QAD ; 5QAE ; 5QAF ; 5QAG ; 5QAH ; 5QAI ; 5QAJ ; 5QAK ; 5QAL ; 5QAM ; 5QAN ; 5QAO ; 5QAP ; 5QAQ ; 5QAR ; 5QAS ; 5QAT ; 5QAU ; 5QAV ; 5QAW ; 5QAX ; 5QAY ; 5QAZ ; 5QB0 ; 5QB1 ; 5QB2 ; 5QB3 ; 5QB4 ; 6GOA ; 6HOO ; 6I5D ; 6P96 ; 6P97 ; 6P98 ; 6P99 ; 6P9C ; 6PK0 ; 6PQI ; 6PSG ; 6PT1 ; 6PT5 ; 6PTU ; 6PXX ; 6Q5B ; 6Q5F ; 6RJ7 ; 6UVK ; 6V1O ; 6XQR ; 6ZRJ ; 6ZRP ; 6ZXI ; 7ASS ; 7AUX ; 7AW5 ; 7DML ; 7JHQ ; 7K5V ; 7KH9 ; 7KHQ ; 7L8O ; 7LXG ; 7O5N ; 7O5Q ; 7O9N ; 7PEH ; 7PEP ; 7PGO ; 7PSF ; 7R6Z

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs: 1 Drugs
Ceftazidime	Drug Info	Approved	Bacterial infection	ICD11: 1A00-1C4Z	[1]

References
1	OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

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