Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME0480)
DME Name Uridine-cytidine kinase 2 (UCK2), Homo sapiens
Synonyms Cytidine monophosphokinase 2; Uridine monophosphokinase 2; Testis-specific protein TSA903; UCK 2; UCK2
Gene Name UCK2
UniProt ID
UCK2_HUMAN
Gene ID
7371
EC Number    EC: 2.7.1.48     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.48
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILS
QDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRK
EETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQ
ILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNG
CLNGYTPSRKRQASESSSRPH
Structure
1UDW ; 1UEI ; 1UEJ ; 1UFQ ; 1UJ2 ; 1XRJ ; 6N53 ; 6N54 ; 6N55
Pathway Drug metabolism - other enzymes (hsa00983 )
Metabolic pathways (hsa01100 )
Pyrimidine metabolism (hsa00240 )
Function This enzyme phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate but does not phosphorylate deoxyribonucleosides or purine ribonucleosides. It can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)- acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Uridine
 Drug Info Approved Depression ICD11: 6A71 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
RX-3117
 Drug Info Phase 2 Bladder cancer ICD11: 2C94 [2]
RX-3117
 Drug Info Phase 2 Bladder cancer ICD11: 2C94 [3]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Cytidine
 Drug Info Investigative Discovery agent ICD: N.A. [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          2 Drugs
Uridine
 Drug Info Approved Depression Km = 0.05 microM [1]
Cytidine
 Drug Info Investigative Discovery agent Km = 0.086 microM [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008284 RX-3117 RX-MP Unclear - Unclear RX-3117 [4]
References
1 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6.
2 The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2
3 A multicenter phase 1/2 study investigating the safety, pharmacokinetics, pharmacodynamics and efficacy of a small molecule antimetabolite, RX-3117, plus nab-paclitaxel in pancreatic adenocarcinoma
4 Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360)

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