| General Information of DME (ID: DME1022) |
| DME Name |
Tyramine oxidase (tynA), Escherichia coli
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| Synonyms |
Copper amine oxidase; Primary amine oxidase; 2-phenylethylamine oxidase; JW1381; b1386; Bacterial maoA; tynA
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| Gene Name |
tynA
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 1.4.3.21 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH2 donor oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.4.3.21
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| Lineage |
Species: Escherichia coli (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MGSPSLYSARKTTLALAVALSFAWQAPVFAHGGEAHMVPMDKTLKEFGADVQWDDYAQLF
TLIKDGAYVKVKPGAQTAIVNGQPLALQVPVVMKDNKAWVSDTFINDVFQSGLDQTFQVE
KRPHPLNALTADEIKQAVEIVKASADFKPNTRFTEISLLPPDKEAVWAFALENKPVDQPR
KADVIMLDGKHIIEAVVDLQNNKLLSWQPIKDAHGMVLLDDFASVQNIINNSEEFAAAVK
KRGITDAKKVITTPLTVGYFDGKDGLKQDARLLKVISYLDVGDGNYWAHPIENLVAVVDL
EQKKIVKIEEGPVVPVPMTARPFDGRDRVAPAVKPMQIIEPEGKNYTITGDMIHWRNWDF
HLSMNSRVGPMISTVTYNDNGTKRKVMYEGSLGGMIVPYGDPDIGWYFKAYLDSGDYGMG
TLTSPIARGKDAPSNAVLLNETIADYTGVPMEIPRAIAVFERYAGPEYKHQEMGQPNVST
ERRELVVRWISTVGNYDYIFDWIFHENGTIGIDAGATGIEAVKGVKAKTMHDETAKDDTR
YGTLIDHNIVGTTHQHIYNFRLDLDVDGENNSLVAMDPVVKPNTAGGPRTSTMQVNQYNI
GNEQDAAQKFDPGTIRLLSNPNKENRMGNPVSYQIIPYAGGTHPVAKGAQFAPDEWIYHR
LSFMDKQLWVTRYHPGERFPEGKYPNRSTHDTGLGQYSKDNESLDNTDAVVWMTTGTTHV
ARAEEWPIMPTEWVHTLLKPWNFFDETPTLGALKKDK
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| Structure |
1D6U
; 1D6Y
; 1D6Z
; 1DYU
; 1JRQ
; 1LVN
; 1OAC
; 1QAF
; 1QAK
; 1QAL
; 1SPU
; 2W0Q
; 2WGQ
; 2WO0
; 2WOF
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| Pathway |
Biosynthesis of secondary metabolites (ecj01110 ) |
| Glycine, serine and threonine metabolism (ecj00260 ) |
| Metabolic pathways (ecj01100 ) |
| Phenylalanine metabolism (ecj00360 ) |
| Tyrosine metabolism (ecj00350 ) |
| beta-Alanine metabolism (ecj00410 ) |
| Function |
This enzyme can oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary amines.
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