Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1022)
DME Name Tyramine oxidase (tynA), Escherichia coli DME Info
UniProt ID
AMO_ECOLI
EC Number    EC: 1.4.3.21     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH2 donor oxidoreductase
Oxygen acceptor oxidoreductase
EC: 1.4.3.21
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Amphetamine Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-tynA interaction [1], [2]
Description The interaction, between human Cytochrome P450 2D6 and Tyramine oxidase from Escherichia coli which collectively metabolize the drug Amphetamine, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Mechanistic elucidation of amphetamine metabolism by tyramine oxidase from human gut microbiota using molecular dynamics simulations. J Cell Biochem. 2019 Jan 30.
2 Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives. Xenobiotica. 1999 Jul;29(7):719-32.

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