Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1106)
DME Name Arylamine N-acetyltransferase (NAT), Klebsiella pneumoniae
Synonyms N-hydroxyarylamine O-acetyltransferase; nhoA; nhoA_1; SAMEA1713070_01652
Gene Name nhoA_1
UniProt ID
A0A1C3Q7F5_KLEPN
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Klebsiella pneumoniae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae
Subspecies: Klebsiella pneumoniae subsp. Ozaenae
Subspecies: Klebsiella pneumoniae subsp. Rhinoscleromatis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSPFLRAYFSRLGWTGEPDVSIDTLRQLHLQHNSAIPFENLDVLLPREIHLDDLALEAKL
IAGRRGGYCFEQNGLLERALREIGFNVRSLLGRVVLANPPQMPPRTHRLLLVEVAGERWI
ADVGFGGQTLTAPIKLLADIPQQTPHGSYRLVHEGDEWTLQFNHHEHWQSMYHFDLGRQY
ASDYVMGNFWSAHWPQSHFRHHLLMCRHLPDGGKMTLTNFHFTHWENNHVVEKVDFADVS
ALYEGLQTRFGLGVDDPKHGFSEAALAAVMAAFDTHPEAGK
Function This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Asacolitin
 Drug Info Investigative Inflammatory bowel disease ICD11: DD72 [1]
References
1 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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