Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1108)
DME Name Arylamine N-acetyltransferase (NAT), Klebsiella oxytoca
Synonyms N-hydroxyarylamine O-acetyltransferase; nhoA; B9P90_27370; KOX_19355
Gene Name NAT
UniProt ID
A0A0H3HB23_KLEOK
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Klebsiella oxytoca     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella oxytoca
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MHSDSFDLSLYFRRIGYSGPAAADTATLHALMRHQLFAIPFENLDVQAGKIVSMEPDDIA
NKLLRQRRGGYCYELNGLFTMALEALGIAWRFVAARPMFYPARRPKTHMAVVAEVEGRQW
LCDLGFGSYGIRAPLALDELDTDIIQDFDTFRLSRDAHGDYLLQAKVEGSWANQYGFDLS
PQEWIDFAPANFLNSTHPDAVFVQKLLVIQHQPEGRFILLGNTLKSITADRVEKQRLEDD
EIAHVLEQRFALSAR
Function This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Asacolitin
 Drug Info Investigative Inflammatory bowel disease ICD11: DD72 [1]
References
1 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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