Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1108)
DME Name Arylamine N-acetyltransferase (NAT), Klebsiella oxytoca DME Info
UniProt ID
A0A0H3HB23_KLEOK
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Klebsiella oxytoca     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella oxytoca
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      18 Xenobiotics
                              Antimicrobial peptide HsAp1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02284   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide HsAp1 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 50.5 microM) [1]
                              Antimicrobial peptide HsAp2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02285   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide HsAp2 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 50.5 microM) [1]
                              Antimicrobial peptide HsAp3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02286   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide HsAp3 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 50.5 microM) [1]
                              Antimicrobial peptide HsAp4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02287   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide HsAp4 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 50.5 microM) [1]
                              ccTP derivative Arg13 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01812   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation ccTP derivative Arg13 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 4.0 microM) [2]
                              ccTP derivative Arg4,8 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01815   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation ccTP derivative Arg4,8 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 6.1 microM) [2]
                              ccTP derivative Arg4,8,13 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01814   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation ccTP derivative Arg4,8,13 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 2.4 microM) [2]
                              ccTP derivative Arg4,8,13 Lys18 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01813   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation ccTP derivative Arg4,8,13 Lys18 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 4.1 microM) [2]
                              Cyclopsychotride-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03039   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclopsychotride-A inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 5.80 microM) [3], [4]
                              Hydramacin Hm-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03609   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hydramacin Hm-1 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca [5], [6]
                              Kalata-B1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03693   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Kalata-B1 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 54.8 microM) [7]
                              Microcin L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04114   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Microcin L inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca [8], [9]
                              Neutrophil defensin HANP-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04259   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neutrophil defensin HANP-1 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca [10]
                              Neutrophil defensin HANP-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04261   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neutrophil defensin HANP-2 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca [10]
                              Neutrophil defensin HANP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04265   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neutrophil defensin HANP-3 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca [10]
                              Neutrophil defensin HANP-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04268   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neutrophil defensin HANP-4 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca [10]
                              RTD peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04863   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation RTD peptide inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 2.0 microM) [2]
                              Tricystine cyclic cystine TP Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05170   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tricystine cyclic cystine TP inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Klebsiella oxytoca (MIC = 2.1 microM) [2]
References
1 A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. Peptides. 2012 Dec;38(2):389-94.
2 Marked increase in membranolytic selectivity of novel cyclic tachyplesins constrained with an antiparallel two-beta strand cystine knot framework. Biochem Biophys Res Commun. 2000 Jan 27;267(3):783-90.
3 An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8913-8.
4 Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes. J Nat Prod. 1994 Dec;57(12):1619-25.
5 Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev Comp Immunol. 2009 Apr;33(4):559-69.
6 Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J Biol Chem. 2009 Jan 16;284(3):1896-905.
7 Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions. J Biol Chem. 2012 Dec 21;287(52):43884-98.
8 Genetic analysis and complete primary structure of microcin L. Antimicrob Agents Chemother. 2004 Feb;48(2):505-13.
9 Wild-type Escherichia coli producing microcins B17, D93, J25, and L; cloning of genes for microcin L production and immunity. Can J Microbiol. 2003 May;49(5):357-61.
10 Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins. Infect Immun. 1996 Nov;64(11):4444-9.

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