Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1442)
DME Name Cytochrome P450 130A1 (cyp130), Mycobacterium tuberculosis
Synonyms Cytochrome P450 family 130 subfamily A member 1; P450 130A1; MTCY50.26; P450 130A1; Rv1256c; cyp130A1
Gene Name cyp130
UniProt ID
CP130_MYCTU
EC Number    EC: 1.14.15.29     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.29
Lineage    Species: Mycobacterium tuberculosis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHADVWSAAR
DHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVETVEPTV
RKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDWTQFDGWTQAIVAANAVD
GATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVGADGDTAGTLSILAFTFTM
VTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPDAVEELLRLTSPVQGLARTTTRD
VTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNILTFSHGAHHCLGAAAA
RMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVTS
Structure
2UUQ ; 2UVN ; 2WGY ; 2WH8 ; 2WHF
Function This enzyme catalyzes the N-demethylation of dextromethorphan yielding 3-methoxymorphinan.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Dextromethorphan hydrobromide
 Drug Info Approved Atherosclerosis ICD11: BA80 [1]
References
1 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.

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