Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1442)
DME Name Cytochrome P450 130A1 (cyp130), Mycobacterium tuberculosis DME Info
UniProt ID
CP130_MYCTU
EC Number    EC: 1.14.15.29     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.29
Lineage    Species: Mycobacterium tuberculosis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Dextromethorphan hydrobromide Click to Show/Hide the Full List of HOSPPI:        8 HOSPPI
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp130 interaction [1], [2]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 130A1 from Mycobacterium tuberculosis which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2B6 (CYP2B6) Click to Show/Hide the Cometabolization Info
DME ID DME0020 DME Info
Uniprot ID
CP2B6_HUMAN
Interaction Name CYP2B6-cyp130 interaction [1], [3]
Description The interaction, between human Cytochrome P450 2B6 and Cytochrome P450 130A1 from Mycobacterium tuberculosis which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp130 interaction [1], [4]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 130A1 from Mycobacterium tuberculosis which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp130 interaction [1], [5]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 130A1 from Mycobacterium tuberculosis which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp130 interaction [1], [6]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 130A1 from Mycobacterium tuberculosis which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp130 interaction [1], [7]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 130A1 from Mycobacterium tuberculosis which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-cyp130 interaction [1], [8]
Description The interaction, between human Cytochrome P450 3A7 and Cytochrome P450 130A1 from Mycobacterium tuberculosis which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp130 interaction [1], [4]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 130A1 from Mycobacterium tuberculosis which collectively metabolize the drug Dextromethorphan hydrobromide, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614.
2 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
3 Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes. Biopharm Drug Dispos. 1999 Oct;20(7):341-6.
4 Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A. J Pharm Pharmacol. 1998 Sep;50(9):997-1004.
5 Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet. 2009;48(11):689-723.
6 Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov;29(11):1514-20.
7 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
8 Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol. 1994 Jul 5;48(1):173-82.

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