Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN008)
DME Name Dopamine beta-hydroxylase (DBH), Homo sapiens
Gene Name DBH
UniProt ID
DOPO_HUMAN
EC Number    EC: 7.1.1.9     (Click to Show/Hide the Complete EC Tree)
Translocase
Hydron translocase
Hydron translocase
EC: 7.1.1.9
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLE
LSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQK
GQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSL
EAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKG
FSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLA
AWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRF
NAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKV
VTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGG
FGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFT
SVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQ
GRSPAGPTVVSIGGGKG
Structure
4ZEL ;
Function Conversion of dopamine to noradrenaline.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Levodopa
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Methyldopate Hydrochloride
 Drug Info Approved Hypertension ICD11: BA00-BA04 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR001487 Dopamine Norepinephrine Oxidation - Hydroxylation Levodopa [1]
MR008690 Alpha-methyldopamine Alpha-methylnorepinephrine Oxidation - Hydroxylation Methyldopate Hydrochloride [2]
MR012694 Phenylethylamine Phenylethanolamin Oxidation - Hydroxylation Phenylethylamine [3]
References
1 DrugBank(Pharmacology-Metabolism)Levodopa
2 DrugBank(Pharmacology-Metabolism):Methyldopate Hydrochloride
3 Discriminative stimulus properties of beta-phenylethylamine, deuterated beta-phenylethylamine, phenylethanolamine and some metabolites of phenylethylamine in rodents

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