Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001487)
Formula
DBH
SVG example
Hydroxylation
Reactant Dopamine Product Norepinephrine
Reactant Info Product Info
Metabolic Enzyme Dopamine beta-hydroxylase (DBH) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001498 Levodopa Dopamine Oxidation - Decarboxylation Levodopa [1]
MR008912 DEC-TA-870 Dopamine Unclear - Unclear Docarpamine [2]
MR009124 Levodopa Dopamine Unclear - Unclear ABBV-951 [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001486 Dopamine 3,4-Dihydroxyphenylacetaldehyde (DOPAL) Oxidation - Oxidative Deamination Levodopa [4]
MR001485 Dopamine 3-Methoxytyramine Conjugation - O-Methylation Levodopa [4]
MR001488 Dopamine Dopamine-3-O-glucuronide Oxidation - N-Dealkylation Levodopa [4]
MR001490 Dopamine Dopamine-3-O-sulfate Conjugation - Sulfation Levodopa [4]
MR001489 Dopamine Dopamine-4-O-glucuronide Oxidation - N-Dealkylation Levodopa [4]
MR001491 Dopamine Dopamine-4-O-sulfate Conjugation - Sulfation Levodopa [4]
MR008915 Dopamine 3,4-dihydroxyphenylacetic acid Unclear - Unclear Docarpamine [2]
MR008913 Dopamine 3-methoxytyramine Unclear - Unclear Docarpamine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014193 Droxidopa Norepinephrine Oxidation - Decarboxylation Droxidopa [5]
References
1 Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34.
2 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs
3 Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease
4 DrugBank(Pharmacology-Metabolism)Levodopa
5 FDA LABEL:Droxidopa

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