Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000097)
DM Name	N-monodesmethyl diltilazem

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Diltiazem hydrochloride	Oxidation - N-Demethylation	Diltiazem hydrochloride	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 2D6 (CYP2D6)	DME0009	N,O-didesmethyl diltiazem	Oxidation - O-Demethylation	Diltiazem hydrochloride	[2] , [1]
Liver esterases (LE)	DMEN062	Deacetyl N-monodesmethyl diltiazem	Conjugation - Acetylation	Diltiazem hydrochloride	[2]

Full List of Drug(s) That Produce This DM By Metabolism
Diltiazem hydrochloride		DR0509	Approved		Essential hypertension

References
1	Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. Drug Metab Dispos. 2002 Jan;30(1):1-3.
2	Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):199-206. doi: 10.1007/BF03188796.

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