General Information of DME (ID: DMEN062)
DME Name	Liver esterases (LE), .
Gene Name	LE
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs:          1 Drugs
Etomidate	Drug Info	Approved	Anaesthesia	ICD11: 9A76-9A78	[1]

Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF MR000869 Diltiazem hydrochloride Deacetyl diltiazem Oxidation - Deacetylation Diltiazem hydrochloride [2] MR000863 N-monodesmethyl diltilazem Deacetyl N-monodesmethyl diltiazem Conjugation - Acetylation Diltiazem hydrochloride [3] MR008759 Etomidate ETA Hydrolysis - Hydrolyzation Etomidate [1] MR008087 Hetacillin Ampicillin Hydrolysis - Hydrolysis Hetacillin [4] MR008088 Hetacillin Acetone Hydrolysis - Hydrolysis Hetacillin [4] MR002348 Tazarotene Tazarotenic acid Hydrolysis - Hydrolysis Tazarotene [5] MR007921 Travoprost Travoprost Free Acid Hydrolysis - Esterase hydrolysis Travoprost [6] ⏷ Show the Full List of 7 MR(s)

References
1	Simultaneous Determination of Etomidate and Its Major Metabolite, Etomidate Acid, in Urine Using Dilute and Shoot Liquid Chromatography-Tandem Mass Spectrometry
2	Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. Drug Metab Dispos. 2002 Jan;30(1):1-3.
3	Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):199-206. doi: 10.1007/BF03188796.
4	Biotransformation of hetacillin to ampicillin in man
5	Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis Clin Pharmacokinet. 1999 Oct;37(4):273-87. doi: 10.2165/00003088-199937040-00001.
6	Determination of travoprost and travoprost free acid in human plasma by electrospray HPLC/MS/MS

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