Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000101)
DM Name
Deacetyl diltiazem
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Liver esterases (LE) DMEN062
Diltiazem hydrochloride
Oxidation - Deacetylation Diltiazem hydrochloride [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 2D6 (CYP2D6) DME0009
Deacetyl O-desmethyl diltiazem
Oxidation - O-Demethylation Diltiazem hydrochloride [2] , [1]
Full List of Drug(s) That Produce This DM By Metabolism
Diltiazem hydrochloride DR0509 Approved Essential hypertension
References
1 Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. Drug Metab Dispos. 2002 Jan;30(1):1-3.
2 Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):199-206. doi: 10.1007/BF03188796.

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