Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000130)
DM Name	6-hydroxymethylandrosta-1,4,6-triene-3,17-dione

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2B6 (CYP2B6)	DME0020	Exemestane	Oxidation - Deamination	Exemestane	[1]
Cytochrome P450 3A (CYP3A)	DMEN065	Exemestane	Oxidation - Deamination	Exemestane	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Exemestane		DR0675	Approved		Breast cancer

References
1	In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17beta-dihydroexemestane. Pharmacol Res Perspect. 2017 Apr 27;5(3):e00314.

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