Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000320)
DM Name
NO
Synonyms
nitric oxide; nitrogen monoxide; Mononitrogen monoxide; 10102-43-9; INOmax; Nitrosyl radical; Nitrogen oxide (NO); Amidogen, oxo-; nitrosyl; nitrogen monooxide; Nitric oxide trimer; Inovent; EDRF; CHEBI:16480; endothelium-derived relaxing factor; OHM-11771; monoxyde d'azote; oxoazanyl; oxido nitrico; oxyde azotique; Stickstoffmonoxid; Nitrogen(II) oxide; monoxido de nitrogeno; Stickstoff(II)-oxid; INOmax (TN); oxido de nitrogeno(II); Nitrosoradical; [NO]; oxidonitrogen(.); OHM 11771; GENOSYL; Nitric oxide, 98.5%; NITRIC OXIDE [MI]; Nitric oxide (JAN/USAN); NITRIC OXIDE [JAN]; NITRIC OXIDE [HSDB]; NITRIC OXIDE [VANDF]; NITRIC OXIDE [MART.]; NITRIC OXIDE [WHO-DD]; CHEMBL1200689; DTXSID1020938; NITRIC OXIDE [EMA EPAR]; (.)NO; NO(.); NITRIC OXIDE [ORANGE BOOK]; NITRIC OXIDE [EP MONOGRAPH]; (NO)(.); DB00435; C00533; D00074
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 30.006 Topological Polar Surface Area 18.1
Heavy Atom Count 2 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 1
PubChem CID
145068
Complexity
2
Formula
NO
Canonical SMILES
[N]=O
InChI
InChI=1S/NO/c1-2
InChIKey
MWUXSHHQAYIFBG-UHFFFAOYSA-N
IUPAC name
nitric oxide
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Nitric oxide synthase brain (NOS1) DME0122
Arginine
Unclear - Unclear L-Proline [1]
Nitric oxide synthase brain (NOS1) DME0122
Arginine
Unclear - Unclear Arginine [2] , [3]
Nitrite reductase (nirS) DMEN188
Nitrite
Unclear - Unclear Nitrite [4] , [5]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
NO dismutase (NOD) DMEN189
N2
Unclear - Unclear Nitrite [4]
Full List of Drug(s) That Produce This DM By Metabolism
L-glutamine DR0950 Approved Sickle-cell anaemia
Arginine DR5046 Approved Growth hormone deficiency
L-Proline DR5757 Approved Malnutrition
Hydroxyurea DR5877 Approved Chronic myelogenous leukaemia
Glyceryl trinitrate DR2513 Phase 4 Acute coronary syndrome
Nitrite DR2117 Investigative Discovery agent
Nitrosoglutathione DR2448 Investigative Discovery agent
References
1 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses
2 Arginine Metabolism Revisited
3 Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer
4 A new intra-aerobic metabolism in the nitrite-dependent anaerobic methane-oxidizing bacterium Candidatus 'Methylomirabilis oxyfera'
5 Nitrite and nitrate: cardiovascular risk-benefit and metabolic effect

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