Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5046)
Drug Name
Arginine
Synonyms
DL-Arginine hydrochloride; 32042-43-6; 2-Amino-5-guanidinopentanoic acid hydrochloride; argininhydrochlorid; DL-Arginine HCl; 220144-84-3; H-DL-Arg-OH.xHCl; DL-(+/-)-Arginine Hydrochloride; 1-Hydrochloride arginine; NSC7914; Arginine monochloride; 2-Amino-5-guanidinovaleric acid monohydrochloride; WLN: MUYZM3YZVQ & DL-Arginine hydrochloride, 98%, anhydrous; Arginine monohydrochloride, L-(+)-; ARGININE, (L); L(+)-Arginine hydrochloride; D-Arginine, hydrochloride (1:1); EINECS 250-903-0; EINECS 239-674-8
Indication Growth hormone deficiency [ICD11: 5A60-5A61] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 174.2 Topological Polar Surface Area 128
Heavy Atom Count 12 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
6322
ChEBI ID
CHEBI:16467
CAS Number
74-79-3
TTD Drug ID
D0F5DO
Formula
C6H14N4O2
Canonical SMILES
C(C[C@@H](C(=O)O)N)CN=C(N)N
InChI
InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChIKey
ODKSFYDXXFIFQN-BYPYZUCNSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Guanidinoacetate DM014824
763
Unclear - Unclear 1 [2]
L-Agmatine DM019921 N. A. Unclear - Unclear 1 [2]
L-Homoarginine DM014925
9085
Unclear - Unclear 1 [2]
NO DM000320
145068
Unclear - Unclear 1 [2] , [3]
Ornithine DM000321
6262
Unclear - Unclear 1 [2]
Creatine DM014821
586
Unclear - Unclear 2 [2]
L-Glutamyl-y-semialdehyde DM019923 N. A. Unclear - Unclear 2 [2]
Putrescine DM003089
1045
Unclear - Unclear 2 [2]
Glutamate DM000317
33032
Unclear - Unclear 3 [2]
L-A1Pyrroline-5-carboxylate DM019924 N. A. Unclear - Unclear 3 [2]
SPD DM001721
1102
Unclear - Unclear 3 [2]
Y-amino-butyraldehyde DM019922 N. A. Unclear - Unclear 3 [2]
#NAME? DM000332
119
Unclear - Unclear 4 [2]
Alpha-ketoglutarate DM000323
164533
Unclear - Unclear 4 [2]
L-Glutamine DM001343
5961
Unclear - Unclear 4 [2]
L-Proline DM000322
145742
Unclear - Unclear 4 [2]
Spermine DM001722
1103
Unclear - Unclear 4 [2]
⏷ Show the Full List of 17  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR012733 Arginine L-Agmatine Unclear - Unclear AZIN2 [2]
MR012739 Arginine L-Ornithine Unclear - Unclear AGMAT [2]
MR012748 Arginine Guanidinoacetate Unclear - Unclear GATM [2]
MR012750 Arginine L-Homoarginine Unclear - Unclear GATM [2]
MR012751 Arginine NO Unclear - Unclear NOS1 [2], [3]
MR012749 Guanidinoacetate Creatine Unclear - Unclear GAMT [2]
MR012734 L-Agmatine Putrescine Unclear - Unclear AGMAT [2]
MR012740 L-Ornithine Putrescine Unclear - Unclear ODC1 [2]
MR012741 L-Ornithine L-Glutamyl-y-semialdehyde Unclear - Unclear ODC1 [2]
MR012742 L-Glutamyl-y-semialdehyde L-Glutamate Unclear - Unclear Unclear [2]
MR012746 L-Glutamyl-y-semialdehyde L-A1Pyrroline-5-carboxylate Unclear - Unclear SPONTANEOUS [2]
MR012735 Putrescine Spermidine Unclear - Unclear SRM [2]
MR012737 Putrescine Y-amino-butyraldehyde Unclear - Unclear AOC1 [2]
MR012747 L-A1Pyrroline-5-carboxylate L-Proline Unclear - Unclear PYCR3 [2]
MR012743 L-Glutamate GABA Unclear - Unclear gadB [2]
MR012744 L-Glutamate L-Glutamine Unclear - Unclear GLUL [2]
MR012745 L-Glutamate Alpha-Ketoglutarate Unclear - Unclear GLUD [2]
MR012736 Spermidine Spermine Unclear - Unclear SMS [2]
MR012738 Y-amino-butyraldehyde GABA Unclear - Unclear ALDH3A1 [2]
⏷ Show the Full List of 19 MR(s)
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Arginine Metabolism Revisited
3 Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer

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