General Information of Drug Metabolite (DM) (ID: DM000368)
DM Name
H2O
Synonyms
water|7732-18-5|Dihydrogen oxide|Distilled water|Sterile water|Water vapor|Water, deionized|oxidane|Purified water|Water, purified|Water, mineral|Dihydrogen Monoxide|aqua|DHMO|agua|steam|Deionized water|Water, sterile|Water, distilled|CCRIS 6115|Ultrex ii ultrapure|Water for injection|Sterile water for irrigation|Sterile purified water|Water for hemodialysis|acqua|dihydridooxygen|1,3-epoxy-|Wasser|Water, purified sterile|Water, sterile purified|Water purified|Pur-wash|hydrogen hydroxide|Sterile water for injection|EINECS 231-791-2|H2O|Sterile water for inhalation|UNII-059QF0KO0R|Water for inhalation, sterile|NSC 147337|NSC-147337|Water, HPLC|Water, HPLC grade|AQUAFINA|059QF0KO0R|CHEBI:15377|Water, DEPC-Treated|HSDB 8183|Sterile water in plastic container|Deuterium Cdepleted water|MFCD00011332|Water for injection, sterile|Water for irrigation, sterile|HYDROGEN OXIDE (H2O)|DTXSID6026296|R-718|Bacteriostatic water for injection|Sterile water for injection in plastic container|Water for injection, bacteriostatic|Water, for HPLC|Bacteriostatic water for injection in plastic container|HOH|Water; Dihydrogen oxide|NSC 147337; R 718|B1217|Water, distilled, conductivity or of similar purity|(OH2)|[OH2]|H2-O|Water, sterile-filtered, BioReagent, suitable for cell culture|Aqua Purificata|eau|BOUND WATER|Adelheidsquelle|Tritiotope|Wiesbaden|Hydroxy radical|Water,deionized|Water,distilled|Water,sanitized|Adelheid aqua|Aqua adelheid|Aqua wiesbaden|Water,purified|Water,sterile|Wiesbaden aqua|Aqua wildbad|Wildbad aqua|water-|DI water|Aqua pro injectione|Pure Water Density Standard, UKAS ISO/IEC17025 and ISO Guide 34 certified, density: 0.9982 g/mL at 20 C, density: 0.9970 g/mL at 25 C|Water,bacteriostatic|Water for injections|Water, ACS reagent|Water, HPLC Plus|Water, LCMS grade|Water, PCR Reagent|Sterile water (TN)|Water, LC/MS|Water, Endotoxin-free|an unknown oxygen source|WATER [VANDF]|Water, purified (USP)|H-OH|WATER [INCI]|ddWater (endotoxin-free)|Purified water (JP17)|Water (JP17/USP)|Water, for TOC analysis|AQUA [INCI]|WATER [JAN]|WATER [WHO-DD]|WATER [MI]|D0SQ1W|Distilled water, for HPLC|InChI=1/H2O/h1H2|Water, deionized (<2uS)|Water, RNase, DNase-free|Pure Water Density Standard|Sterile water for injections|Water for irrigation,sterile|Water, HPLC gradient grade|Water, deionized (<10uS)|Water, demineralized, p.A.|Water,bacteriostatic injection|Water for injection (JP17)|Water, for ion chromatography|Water,Reagent(Deionizedwater)|B1217 [LANGUAL]|Density Standard 998 kg/m3|Aqua sterilisata pro injectione|Water, ultrapure, HPLC Grade|DTXCID106296|Water, BioPerformance Certified|PURIFIED WATER [MART.]|CHEMBL1098659|Water, Molecular Biology Reagent|XLYOFNOQVPJJNP-UHFFFAOYSA-|diethylpyrocarbonate-treated Water|DTXSID00170378|TUJKJAMUKRIRHC-UHFFFAOYSA-N|Water, Reagent (Deionized water)|Water, tested according to Ph.Eur.|NSC147337|Purified water in containers (JP17)|AKOS015950726|E-Toxate(TM) Water, endotoxin, free|Water with 0.1% trifluoroacetic acid|DB09145|LS-1718|Water, for UHPLC, for mass spectrometry|Q283|Water for injection in containers (JP17)|Water, ultrapure, Spectrophotometric Grade|LS-190909|FT-0666297|FT-0696358|FT-0696590|FT-0696628|FT-0696641|FT-0696971|FT-0697004|FT-0697144|FT-0697158|FT-0697170|FT-0697209|FT-0697243|FT-0697253|FT-0697259|FT-0697294|FT-0697297|FT-0697301|FT-0697341|FT-0697349|FT-0697357|FT-0697405|FT-0697446|FT-0697449|FT-0697507|FT-0697572|FT-0697623|FT-0697627|FT-0697628|FT-0697674|FT-0697714|FT-0697757|FT-0697788|FT-0697792|FT-0697796|FT-0697843|FT-0697856|FT-0697866|FT-0697871|FT-0697889|FT-0697898|FT-0697905|FT-0697910|FT-0697922|FT-0698010|FT-0698017|FT-0698043|FT-0698101|FT-0698115|FT-0698166|FT-0698169|FT-0698223|FT-0698239|FT-0698270|FT-0698271|FT-0698321|FT-0698348|FT-0698364|FT-0698424|FT-0698457|FT-0698465|FT-0698477|FT-0698494|FT-0698589|FT-0698592|FT-0698708|FT-0698717|FT-0698718|FT-0698751|FT-0698783|FT-0698819|FT-0698821|FT-0698831|FT-0698832|FT-0698834|FT-0698835|FT-0698842|FT-0698843|FT-0698847|FT-0698849|FT-0698856|FT-0698897|FT-0698914|FT-0698990|FT-0698992|FT-0698993|FT-0698996|FT-0698999|FT-0699000|FT-0699001|FT-0699002|FT-0699003|FT-0699004|FT-0699005|FT-0699007|FT-0699017|FT-0699037|FT-0699049|FT-0699053|FT-0699078|FT-0699128|FT-0699173|FT-0699177|FT-0699181|FT-0699195|FT-0699197|FT-0699222|FT-0699237|FT-0699244|FT-0699257|FT-0699263|FT-0699270|FT-0699281|FT-0699301|FT-0699381|FT-0699391|FT-0699491|FT-0699565|FT-0699582|FT-0699656|FT-0699660|FT-0699667|FT-0699668|FT-0699680|FT-0699707|FT-0699726|FT-0699727|FT-0699728|FT-0699749|FT-0699751|FT-0699763|FT-0699780|FT-0699822|FT-0699826|Sterile purified water in containers (JP17)|Water, ACS reagent, for ultratrace analysis|Water, packaged for use in deposition systems|C00001|D00001|Water, deuterium-depleted, 99.99995 atom %|Q274959|Q427071|Water, deuterium-depleted, <=1 ppm (Deuterium oxide)|Water, for HPCE, for luminescence, for UV-spectroscopy|Density Standard 998 kg/m3, H&D Fitzgerald Ltd. Quality|Water, for molecular biology, DEPC-treated and sterile filtered|Crackle Test Reference Standard: 0 wt% H2O in 10W30 Motor Oil|Crackle Test Reference Standard: 0.1 wt% H2O in 10W30 Motor Oil|Crackle Test Reference Standard: 0.5 wt% H2O in 10W30 Motor Oil|Crackle Test Reference Standard: 1.0 wt% H2O in 10W30 Motor Oil|Water, 99.999%, contained in 50 ml Swagelok? cylinder for CVD/ALD|Water, deionized 18 megaohm ASTM Type I, suitable for trace metal analysis|Water, for cell biology, free of endotoxins, ultrafiltered and autoclaved|Water, for embryo transfer, sterile-filtered, BioXtra, suitable for mouse embryo|8O|OH2
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 18.015 Topological Polar Surface Area 1
Heavy Atom Count 1 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
PubChem CID
962
Complexity
0
Formula
H2O
Canonical SMILES
O
InChI
InChI=1S/H2O/h1H2
InChIKey
XLYOFNOQVPJJNP-UHFFFAOYSA-N
IUPAC name
oxidane
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Catalase (CAT) DME0090 Reduction - Reduction Hydrogen peroxide [1]
Cellular glutathione peroxidase (GPX1) DME0147 Reduction - Reduction Hydrogen peroxide [1]
Unclear metabolic mechanism (DME-unclear) DMEN305 Unclear - Unclear Stigmasterol [2]
Full List of Drug(s) That Produce This DM By Metabolism
Fospropofol disodium DR5454 Approved Monitored anaesthesia care
Liraglutide DR0962 Approved Diabetes mellitus
Hydrogen peroxide DR0832 Approved Emphysema
Stigmasterol DR2631 Investigative Allergy
References
1 Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9.
2 Degradation of phytosterols in tobacco waste extract by a novel Paenibacillus sp. Biotechnol Appl Biochem. 2017 Nov;64(6):843-850.

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