Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0832)
Drug Name
Hydrogen peroxide
Synonyms
Hydrogen dioxide; Hydrogen dioxide solution; Hydrogen peroxide (H2O2); Hydrogen peroxide solution; Hydrogen peroxide, 30%; Hydrogen peroxide, 90%; Hydrogen peroxide, solution; Inhibine; Interox; Kastone; Lensept; Perone; Perone 30; Perone 35; Albone; Dihydrogen dioxide; Elawox; Hioxyl; Perone 50; Peroxaan; Peroxan; Peroxide; Superoxol; T-Stuff; Wasserstoffperoxid; Waterstofperoxyde; hydrogen peroxide; hydroperoxide; oxydol; perhydrol; 7722-84-1; Albone 35; Albone 35CG; Albone 50; Albone 50CG; Albone 70; Albone 70CG; Albone DS; H2O2
Indication Emphysema [ICD11: CA21] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 34.015 Topological Polar Surface Area 40.5
Heavy Atom Count 2 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
784
ChEBI ID
CHEBI:16240
CAS Number
7722-84-1
TTD Drug ID
D03IDU
Formula
H2O2
Canonical SMILES
[O-2].OO.[U]
InChI
1S/H2O2.O.U/c1-2;;/h1-2H;;/q;-2;
InChIKey
MHAJPDPJQMAIIY-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Oxygen DM004776
977
Reduction - Reduction 1 [2]
H2O DM000368
962
Reduction - Reduction 2 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005135 Hydrogen peroxide Oxygen Reduction - Reduction CAT ... [2]
MR005136 Hydrogen peroxide Water Reduction - Reduction CAT ... [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Catalase (CAT) DME0090 Homo sapiens
CATA_HUMAN
1.11.1.6
[2]
Cellular glutathione peroxidase (GPX1) DME0147 Homo sapiens
GPX1_HUMAN
1.11.1.9
[2]
Cytochrome P450 1B1 (CYP1B1) DME0023 Homo sapiens
CP1B1_HUMAN
1.14.14.1
[3]
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[4]
References
1 Hydrogen Peroxide was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9.
3 NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. J Steroid Biochem Mol Biol. 2000 Sep;74(1-2):11-8.
4 Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis. Drug Metab Dispos. 2006 Dec;34(12):1958-65.

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