General Information of Drug Metabolite (DM) (ID: DM000780)
DM Name
Desloratadine N-glucuronidation
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME0205 Conjugation - Glucuronidation Desloratadine [1] , [2]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 2C8 (CYP2C8) DME0018 Oxidation - Hydroxylation Desloratadine [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Desloratadine DR1761 Approved Allergic rhinitis
References
1 Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase inhibition potential: identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302.
2 A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620.

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