Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001095)
DM Name	Megestrol acetate metabolite M1
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Megestrol acetate	Oxidation - Oxidation	Megestrol acetate	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Megestrol acetate	Oxidation - Oxidation	Megestrol acetate	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 2B17 (UGT2B17)	DME0066	Megestrol acetate metabolite MG1	Conjugation - Glucuronidation	Megestrol acetate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Megestrol acetate		DR1017	Approved		Breast cancer

References
1	Metabolism of megestrol acetate in vitro and the role of oxidative metabolites. Xenobiotica. 2018 Oct;48(10):973-983.

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