| General Information of Drug Metabolite (DM) (ID: DM001133) |
| DM Name |
Oxymetazoline O-glucuronidation
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A9 (UGT1A9)
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DME0042
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| Conjugation - O-Glucuronidation |
Oxymetazoline
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[1] , [2] |
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UDP-glucuronosyltransferase 2A1 (UGT2A1)
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DME0622
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| Conjugation - O-Glucuronidation |
Oxymetazoline
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[1] , [2] |
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UDP-glucuronosyltransferase 2A2(UGT2A2)
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DMEN887
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| Conjugation - O-Glucuronidation |
Oxymetazoline
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Oxymetazoline |
DR1224
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Approved |
Erythema multiforme |
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| References |
| 1 |
In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite. Drug Metab Dispos. 2011 Apr;39(4):693-702.
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| 2 |
Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9. J Pharm Sci. 2011 Feb;100(2):784-93.
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