Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001258)
DM Name	Rucaparib M323 metabolite

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Rucaparib	Oxidation - Oxidation	Rucaparib	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Rucaparib	Oxidation - Oxidation	Rucaparib	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Rucaparib	Oxidation - Oxidation	Rucaparib	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Rucaparib		DR1449	Approved		Ovarian cancer

References
1	Evaluation of absorption, distribution, metabolism, and excretion of [(14)C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors Invest New Drugs. 2020 Jun;38(3):765-775. doi: 10.1007/s10637-019-00815-2.

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