General Information of Drug Metabolite (DM) (ID: DM001264)
DM Name
Rucaparib M337b metabolite
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Oxidation - Oxidation Rucaparib [1]
Cytochrome P450 2D6 (CYP2D6) DME0009 Oxidation - Oxidation Rucaparib [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Oxidation Rucaparib [1]
Full List of Drug(s) That Produce This DM By Metabolism
Rucaparib DR1449 Approved Ovarian cancer
References
1 Evaluation of absorption, distribution, metabolism, and excretion of [(14)C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors Invest New Drugs. 2020 Jun;38(3):765-775. doi: 10.1007/s10637-019-00815-2.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.