| General Information of Drug Metabolite (DM) (ID: DM001286) |
| DM Name |
Hydroxymethyl metabolite of secnidazole
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 3A4 (CYP3A4)
|
DME0001
|
| Oxidation - Oxidation |
Secnidazole
|
[1] , [2] |
|
Cytochrome P450 3A5 (CYP3A5)
|
DME0012
|
| Oxidation - Oxidation |
Secnidazole
|
[1] , [2] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Secnidazole |
DR2431
|
Approved |
Amebiasis |
|
|
| References |
| 1 |
In vitro metabolic profile and drug-drug interaction assessment of secnidazole, a high-dose 5-nitroimidazole antibiotic for the treatment of bacterial vaginosis Pharmacol Res Perspect. 2020 Aug;8(4):e00634. doi: 10.1002/prp2.634.
|
| 2 |
Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis Drugs. 1996 Apr;51(4):621-38. doi: 10.2165/00003495-199651040-00007.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
