Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM002265)
DM Name	Norethindrone acetate metabolite M1,M2

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Norethindrone acetate	Oxidation - Hydroxylation	Norethindrone acetate	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Norethindrone acetate	Oxidation - Hydroxylation	Norethindrone acetate	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 3A4 (CYP3A4)	DME0001	Norethindrone acetate metabolite M3	Oxidation - Dihydroxylation	Norethindrone acetate	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Norethindrone acetate		DR1750	Approved		Menorrhagia

References
1	Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.

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